Sequence analysis of the hemin uptake locus hmu of Yersinia pestis revealed five genes, hmuRSTUV , required for use of hemin and hemoproteins as iron sources. The translated gene products have homologies with proteins of the hemin transport genes of several gram-negative bacteria. The proposed ABC transporter, HmuTUV, is necessary for use of hemin, hemin-albumin, and myoglobin, but not hemoglobin, hemoglobin-haptoglobin, or heme-hemopexin, as iron sources. Thus, the hmu system is not essential for infection in mice via these routes. Two of these are inorganic iron transport systems important to the pathogenesis of plague: i the yersiniabactin-iron transport system Ybt , a siderophore-dependent system 4 , 16 , 18 , 44 , and ii an iron and manganese uptake system, Yfe 5 , 6. Previously we described a third transport system in Y. Heme is an abundant iron-containing compound found within mammals; it is the prosthetic group of a class of proteins referred to as hemoproteins and is the cofactor in reactions involved in various cellular functions including oxygen transport and electron transfer The majority of heme is found intracellularly in the form of hemoglobin, and any free heme or hemoglobin released extracellularly is rapidly sequestered by the serum heme carrier proteins, hemopexin and albumin, or the serum hemoglobin carrier protein, haptoglobin We identified an 8. Introduction of the hmu locus into an Escherichia coli strain containing mutations in heme and enterobactin biosynthesis hemA aroB allows this strain to use hemin as iron and porphyrin sources but only under iron-poor conditions, providing evidence that the entire hemin moiety is transported into the cell and that the Hmu system may be tightly iron regulated
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I find it hard to believe anyone means still using that. High and pessimistic.
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HMU – Meet & Chat with New People
The internet is full of confusing slang. One term you might have come across is HMU. It’s used all over the place: on social media, chats and texts, and even dating apps. But what does HMU mean? In this article we detail what HMU means and give you examples of how, where, and when to use it.
HMU is an internet slang expression that means ‘hit me up’, which means ‘catch up with me later’ or ‘call/text me later’. Learn when and how to.
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